BERBERINE

Berberis vulgaris extract 97% titrated in berberine

Historically used by Ayurveda and Traditional Chinese Medicine as antimicrobial ^{(1) (2) (3)}, berberine is a natural substance extracted from different plant species, including the plant Berberis vulgaris.

Berberine is a natural alkaloid especially effective in the control of blood glucose or sugar, as well as in the control of cholesterol, which suggests its use in the most common chronic metabolic disorders such as diabetes or hyperlipidemia ^{(4) (5) (6) (7)}.

Berberine, endorsed by science

• DIABETES AND CHOLESTEROL:
  

  Research with berberine shows that this active principle has an action comparable to metformin. Considered as the basic treatment of type 2 diabetes, this oral antidiabetic drug shares the same mode of action with berberine: an antihyperglycemic action. Thus, metformin and berberine act to reduce blood sugar levels, avoiding the hyperglycemia characteristic of type 2 diabetes ⁽⁸⁾.

  This positions berberine as one of the most effective supplements for lowering blood glucose. In diabetics, berberine at doses between 0.5-1.5 g per day for an average period of 12 weeks was associated with improvements in all measured glucose parameters but also in the control of lipids ^{(9) (10) (11)}. In addition, berberine can help control the complications associated with overweight and obesity ^{(12) (13) (14)}.

• ANTIOXIDANT ACTION:
  

  Other lines of research with berberine focus on its ability to protect against oxidative stress by reducing damage in different organs ^{(15) (16)}. As a result, studies suggest its action against some neurodegenerative diseases such as Parkinson's or Alzheimer's ^{(17) (18) (19)} or even as a promising substance in the treatment of some types of cancer^{(20) (21) (22)}.

Our Berberine

Our extract of Berberis vulgaris has been standardized to 97% in Berberine, a very high titration that guarantees the effectiveness of the active principle.

Ingredients: For 1 capsule: Berberis vulgaris root extract, titrated in 97% Berberine (250 mg per capsule).
It does not contain allergens or genetically modified organisms (according to directive 2003/89 / EC).

Directions: 1-3 capsules a day with half a glass of water, before the main meals.

Bibliographic references:

1. Kaneda Y, Tanaka T, Saw T. Effects of berberine, a plant alkaloid, on the growth of anaerobic protozoa in axenic culture. Tokai J Exp Clin Med. (1990).
2. Cernáková M, Kostálová D. Antimicrobial activity of berberine--a constituent of Mahonia aquifolium. Folia Microbiol (Praha). (2002)
3. Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs 2010 Oct;19(10):1297-307. doi: 10.1517/13543784.2010.517745.
4. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.J Clin Endocrinol Metab 2008 Jul;93(7):2559-65. doi: 10.1210/jc.2007-2404. Epub 2008 Apr
5. Zhang B, Pan Y, Xu L, Tang D, Dorfman RG, Zhou Q, Yin Y, Li Y, Zhou L, Zhao S, Zou X, Wang L, Zhang M. Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3. Endocrine 2018 Aug 16. doi: 10.1007/s12020-018-1689-y.
6. Cicero AF, Baggioni A. Berberine and Its Role in Chronic Disease. Adv Exp Med Biol 2016;928:27-45.
7. Pirillo A, Catapano AL. Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies. Atherosclerosis 2015 Dec;243(2):449-61. doi: 10.1016/j.atherosclerosis.2015.09.032. Epub 2015 Sep 30.
8. Yin J, Hu R, Chen M, Tang J, Li F, Yang Y, Chen J. Effects of berberine on glucose metabolism in vitro. Metabolism 2002 Nov;51(11):1439-43.
9. Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, Zeng MS, Tu YF, Feng R, Jia WP, Liu J, Deng W, Jiang JD, Gao X. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. PLoS One 2015 Aug 7;10(8):e0134172. doi: 10.1371/journal.pone.0134172. eCollection 2015.
10. Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med 2012;2012:591654. doi: 10.1155/2012/591654. Epub 2012 Oct 15.
11. Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MC. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord 2013 Oct;11(5):366-9. doi: 10.1089/met.2012.0183. Epub 2013 Jun 28.
12. Derosa G, D’Angelo A, Bonaventura A, Bianchi L, Romano D, Maffioli P. Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert Opin Biol Ther 2013 Apr;13(4):475-82. doi: 10.1517/14712598.2013.776037. Epub 2013 Feb 27.
13. Dong SF, Yasui N, Negishb H, Kishimoto A, Sun JN, Ikeda K. Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by Berberine Treatment. Nat Prod Commun 2015 Jun;10(6):895-7.
14. Hao M, Li Y, Liu L, Yuan X, Gao Y, Guan Z, Li W. The design and synthesis of a novel compound of berberine and baicalein that inhibits the efficacy of lipid accumulation in 3T3-L1 adipocytes. Bioorg Med Chem 2017 Oct 15;25(20):5506-5512. doi: 10.1016/j.bmc.2017.08.013. Epub 2017 Aug 9.
15. Abd El-Wahab AE, Ghareeb DA, Sarhan EE, Abu-Serie MM, El Demellawy MA.In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects.BMC Complement Altern Med. 2013 Sep 5; 13():218.
16. Moghaddam HK, Baluchnejadmojarad T, Roghani M, Khaksari M, Norouzi P, Ahooie M, Mahboobi F. Berberine ameliorate oxidative stress and astrogliosis in the hippocampus of STZ-induced diabetic rats. Mol Neurobiol 2014 Apr;49(2):820-6. doi: 10.1007/s12035-013-8559-7. Epub 2013 Oct 10.
17. Ahmed T, Gilani AU, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM. Berberine and neurodegeneration: A review of literature. Pharmacol Rep 2015 Oct;67(5):970-9. doi: 10.1016/j.pharep.2015.03.002.
18. Fan D, Liu L, Wu Z, Cao M. Combating neurodegenerative diseases with the plant alkaloid berberine: molecular mechanisms and therapeutic potential. Curr Neuropharmacol 2018 Apr 19. doi: 10.2174/1570159X16666180419141613.
19. Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res 2010 Mar;24(3):317-24. doi: 10.1002/ptr.2968.
20. Ortiz LM, Lombardi P, Tillhon M, Scovassi AI. Berberine, an epiphany against cancer.Molecules 2014 Aug 15;19(8):12349-67. doi: 10.3390/molecules190812349.
21. Jabbarzadeh Kaboli P, Rahmat A, Ismail P, Ling KH. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer. Eur J Pharmacol 2014 Oct 5;740:584-95. doi: 10.1016/j.ejphar.2014.06.025. Epub 2014 Jun 26.
22. Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q, He B. Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/β-catenin signaling. Int J Oncol 2012 Jul;41(1):292-8. doi: 10.3892/ijo.2012.1423. Epub 2012 Apr 2.